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Health Benefits of Extra Virgin Olive Oil – Podere Spedalone, Pienza
Podere Spedalone · Pienza · Val d'Orcia · Certified Organic IT-BIO-004

Health Benefits of
Extra Virgin Olive Oil

Heart · Brain · Skin · Longevity · The Mediterranean Secret

Cold-Pressed · Organic · Val d'Orcia Heritage
Discover Our EVOO →

Not Just a Condiment.
A Medicine.

For centuries, the people of the Mediterranean have relied on extra virgin olive oil as a cornerstone of their diet — and today, science confirms what tradition always knew. High-quality EVOO is among the most extensively researched foods on earth, with a body of evidence linking it to reduced risk of heart disease, cancer, cognitive decline and premature death.

At Podere Spedalone, our olive trees grow on 33 hectares of Tuscan soil in the Val d'Orcia UNESCO World Heritage landscape. Our oil is cold-pressed, certified organic, and harvested by hand at the ideal moment — when the polyphenol content is at its peak. What ends up in your bottle is not a commodity. It is the result of living soil, ancient varieties and a commitment to quality that begins in the grove.

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Heart Health

Lowers LDL cholesterol, raises HDL, reduces blood pressure and protects arteries from oxidative damage.

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Brain & Cognition

Linked to a 29% lower risk of dying from neurodegenerative disease in a 28-year Harvard study.

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Anti-Inflammatory

Oleocanthal acts similarly to ibuprofen — fighting chronic inflammation at the root of most disease.

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Cancer Protection

Mediterranean populations show consistently lower rates of certain cancers. EVOO's antioxidants are a likely factor.

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Skin & Beauty

Polyphenols stimulate collagen production, reduce oxidative ageing and nourish dry or sensitive skin.

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Longevity

High olive oil intake is associated with an 8–34% lower risk of death from all major disease categories.

A Friend to Your Heart

Among all edible plant oils, extra virgin olive oil has the highest proportion of monounsaturated fatty acids — a type of fat that has been shown to lower "bad" LDL cholesterol while raising "good" HDL cholesterol. But EVOO's benefit to the heart goes far beyond its fat profile.

01

Cholesterol & Blood Pressure

Oleic acid, the primary fatty acid in olive oil, has been shown to lower LDL cholesterol, raise HDL cholesterol and reduce the risk of heart disease and stroke. The compound oleuropein further helps lower blood pressure by protecting LDL from oxidation — the process that makes it dangerous to artery walls.

Research suggests that simply replacing butter or other saturated fats with EVOO is enough to trigger meaningful improvements in cholesterol levels — independently of the oil's fatty acid content, meaning the polyphenols themselves carry additional benefit.

  • Reduces LDL ("bad") cholesterol
  • Raises HDL ("good") cholesterol
  • Lowers systolic blood pressure in hypertensive patients
  • Protects LDL from oxidation
02

The PREDIMED Evidence

The landmark PREDIMED trial — one of the largest dietary studies ever conducted — found that a Mediterranean diet enriched with extra virgin olive oil significantly reduced major cardiovascular events compared to a low-fat diet. The protective effect was especially strong for stroke risk.

A 2014 review of studies covering 841,000 people identified olive oil as the only source of monounsaturated fat associated with reduced risk of both stroke and heart disease. The American Heart Association now recognises EVOO as a heart-healthy fat that helps reduce the disease process.

  • Lower incidence of heart attack and stroke in Mediterranean diet trials
  • The only MUFA source consistently linked to reduced stroke risk
  • Endorsed by the American Heart Association
  • High polyphenol oil outperforms low polyphenol oil in HDL function

28 Years. 90,000 People. One Conclusion.

A Harvard-led study tracked over 90,000 Americans for 28 years and found that regular olive oil consumption was associated with dramatically lower risk of death from every major cause.

−29% Lower risk of death from neurodegenerative disease Harvard / NEJM, 2022
−19% Lower risk of death from cardiovascular disease Harvard / NEJM, 2022
−17% Lower risk of death from cancer Harvard / NEJM, 2022
−18% Lower risk of death from respiratory disease Harvard / NEJM, 2022
−12% Reduced all-cause mortality from just one teaspoon per day Harvard / NEJM, 2022
−55% Reduced risk of developing type 2 diabetes in prediabetic patients Clinicaltrials, 2019

Good for the Heart,
Good for the Brain

Anything that keeps blood vessels healthy also benefits the brain — and olive oil's role in vascular health directly translates to cognitive protection. A 2024 review found that EVOO may reduce the risk of developing Alzheimer's disease by reducing beta-amyloid plaques, neuroinflammation and oxidative stress in the brain.

The anti-inflammatory power of EVOO stems largely from oleocanthal — a phenolic compound found only in fresh, high-quality extra virgin olive oil. Research has shown oleocanthal to act in a similar way to ibuprofen, inhibiting the same inflammatory enzymes (COX-1 and COX-2). Chronic low-grade inflammation is now understood to be a driver behind heart disease, cancer, Alzheimer's, type 2 diabetes and many other conditions.

03

Alzheimer's & Cognitive Decline

Mediterranean cultures — which have consumed olive oil as their primary fat for millennia — consistently show low rates of dementia. The 2022 Harvard study found that those with the highest olive oil intake had a 29% lower risk of dying from neurodegenerative diseases compared to those consuming little or none.

More recent research points to EVOO's ability to cross the blood-brain barrier and directly reduce the accumulation of the proteins associated with Alzheimer's disease, as well as to reduce neuroinflammation — suggesting a protective mechanism that goes beyond general vascular health.

  • Reduces beta-amyloid plaque formation (Alzheimer's marker)
  • Lowers neuroinflammation
  • 29% lower risk of neurodegenerative disease mortality
  • Linked to preserved cognitive function in older adults
04

Oleocanthal: Nature's Ibuprofen

Oleocanthal is responsible for the characteristic peppery bite you feel at the back of the throat when you taste truly fresh, high-quality extra virgin olive oil. That sensation is no accident — it is the same receptor pathway activated by ibuprofen, signalling anti-inflammatory activity.

This compound is found in meaningful quantities only in genuine EVOO — not in refined olive oils, which lose polyphenols during processing. The higher the polyphenol content of an oil, the more oleocanthal it contains. This is why not all olive oils are equivalent: quality matters.

  • Acts on the same pathways as ibuprofen
  • Reduces C-reactive protein (CRP), a key inflammation marker
  • Found only in unrefined extra virgin olive oil
  • Concentration is higher in early-harvest, cold-pressed oils

Cleopatra's Secret.
Science Confirmed.

Legend holds that Cleopatra used olive oil on her skin to maintain her appearance. Whether or not the story is true, the science behind it is solid. The antioxidants, polyphenols and healthy fats in EVOO that benefit the body from the inside also work externally — and dermatologists increasingly acknowledge its value as a natural skin treatment.

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Deep Moisturisation

Olive oil seals in moisture by creating a protective lipid barrier on the skin surface, softening dry and sensitive skin. It is especially effective applied to damp skin after bathing, when pores are more open and absorption is greater. It can also be used on chapped lips and dry cuticles.

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Wound Healing

Research from the Cleveland Clinic highlights that triterpenes and antioxidants in olive oil ease inflammation and stimulate the skin's production of collagen — the protein responsible for generating new skin cells to replace damaged ones. Olive oil also has antimicrobial properties, helping prevent infection in minor wounds.

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Anti-Ageing

Polyphenols in olive oil stimulate collagen synthesis and protect against oxidative stress from free radicals — a key driver of skin ageing. Studies suggest that regular use helps maintain skin elasticity and reduces the depth and appearance of fine lines and wrinkles. Oxidative stress decreases both collagen and elastin, causing skin to sag.

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Natural Makeup Remover

A small amount of olive oil on a cotton pad effectively removes even waterproof makeup — including mascara — because it is a lipid that dissolves oil-based cosmetics. Dermatologists suggest following with a gentle cleanse to remove any residue, making it a natural and gentle alternative to synthetic removers.

A note on application: apply olive oil to damp skin in a small amount, allow it to absorb for a few minutes before dressing. It is suitable for dry and sensitive skin but may cause breakouts in those with oily or acne-prone skin. As with all topical treatments, a patch test on a small area is advisable before full use.

How to Make It
Part of Every Day

The benefits of extra virgin olive oil accumulate with consistent, daily use — not occasional large quantities. Health experts broadly recommend around 1.5 tablespoons (approximately 20–25 ml) per day as a meaningful amount for cardiovascular benefit, used as a replacement for saturated fats rather than an addition on top of them.

🌅 Morning Ritual

A small spoonful of high-quality EVOO on an empty stomach in the morning is a traditional practice in olive-growing cultures. It is thought to activate digestive enzymes, support gut lining health, and deliver a concentrated dose of polyphenols before the day's meals dilute their absorption. One teaspoon to one tablespoon is sufficient.

🥗 On Everything Raw

Use EVOO generously as a finishing oil — drizzled over salads, vegetables, grilled fish, soups, and bread. The polyphenols and oleocanthal in extra virgin olive oil are most potent when not exposed to high heat. Raw application maximises the health benefit while also allowing fat-soluble vitamins (A, D, E, K) from other foods to be absorbed properly.

🍳 Light Cooking

Despite the widespread myth, EVOO is stable at moderate cooking temperatures. Its smoke point (~180–210°C depending on quality) is well above the temperatures used for most home cooking — sautéing, roasting at moderate heat and pan-searing. Use it freely for everyday cooking, reserving your finest, most polyphenol-rich bottles for raw application.

🫙 Replace, Don't Add

The research is clear: the benefit comes from using olive oil instead of butter, lard or seed oils — not from pouring it on top of an otherwise unchanged diet. Swap butter on bread for a drizzle of EVOO and a pinch of sea salt. Replace vegetable oil in cooking. Use EVOO-based dressings instead of cream-based ones. Small, consistent substitutions make the difference.

🫒 From the Owners of Podere Spedalone

Our Morning Shot

Every morning, before breakfast, we take a small shot of our own extra virgin olive oil — followed immediately by the juice of half a freshly squeezed lemon. It takes about thirty seconds and has become as automatic as making coffee. The lemon cuts through the oil's richness and adds vitamin C, which is thought to enhance the absorption of some of the oil's fat-soluble compounds.

We recommend it to our guests and to anyone who asks — but with one important condition: it only makes sense with genuinely high-quality extra virgin olive oil. A thin, flavourless oil from a supermarket shelf will not give you the same result. The peppery bite, the grassy aroma, the slight bitterness — those are the signs that the polyphenols are still alive and present. If your oil tastes like nothing, it probably does nothing.

Morning olive oil shot at Podere Spedalone Extra virgin olive oil shot with lemon at Podere Spedalone

Not All Olive Oils
Are Created Equal

The health benefits of olive oil are not uniform across all products bearing the label. The difference lies in polyphenol content — the bioactive compounds responsible for most of EVOO's anti-inflammatory, antioxidant and cardiovascular benefits. Polyphenols are destroyed by heat, light, oxygen and time.

Refined olive oils — those labelled simply "olive oil" or "light olive oil" — have been processed in ways that strip most of these compounds. What remains is primarily fat, with little of the pharmacological benefit. Only genuine, cold-pressed extra virgin olive oil retains the full polyphenol profile that science has studied.

The Active Compounds in Our EVOO

Podere Spedalone's olive oil is cold-pressed from traditional Tuscan varieties — Canino, Olivastra, Frantoio — harvested early in the season when polyphenol concentration is highest. Each variety contributes a distinct polyphenol and fatty acid profile, resulting in oils of exceptional quality, complexity and health value.

The EU permits olive oil producers to make authorised health claims regarding polyphenols and cardiovascular protection (Regulation EU 432/2012) on oils that meet a minimum polyphenol threshold of 5 mg of hydroxytyrosol and its derivatives per 20 g of oil. Our oils are produced to exceed this standard.

Oleocanthal Oleacein Oleuropein Hydroxytyrosol Tyrosol Squalene Vitamin E (α-Tocopherol) Vitamin K Oleic Acid (MUFA) Beta-Sitosterol
05

Diabetes & Blood Sugar

Extra virgin olive oil has been shown to improve insulin sensitivity and blood sugar regulation. A 2019 study found that people with prediabetes taking a polyphenol-enriched olive oil daily were 55% less likely to develop type 2 diabetes compared to a control group. A 2017 meta-analysis also found that EVOO supplementation significantly reduced fasting blood sugar in people already living with type 2 diabetes.

  • 55% lower risk of diabetes progression in prediabetic patients
  • Improved insulin sensitivity
  • Reduced fasting plasma glucose
  • Polyphenol content appears to be the key variable
06

Weight & Metabolic Health

Olive oil is calorie-dense — but its relationship with weight is more nuanced than simple calorie arithmetic. Numerous studies have found that diets high in olive oil promote greater weight loss than diets low in olive oil, likely because of the satiety effect of monounsaturated fats and the metabolic benefits of its anti-inflammatory compounds. When used as a primary fat in the context of a Mediterranean-style diet, EVOO supports — not undermines — healthy body weight.

  • Greater weight loss in diets high in olive oil vs. low-fat diets
  • Satiety effect of monounsaturated fats
  • Anti-inflammatory profile supports metabolic health
  • Beneficial when used as replacement fat, not addition

Read More from
These Sources

The research and information on this page draws on peer-reviewed studies and reporting from recognised health institutions and publications. If you would like to explore further, the following links are a good starting point.

Cleveland Clinic 6 Major Benefits of Extra Virgin Olive Oil

Registered dietitian Julia Zumpano covers heart health, anti-inflammatory properties, longevity data and more from a clinical perspective.

Read Article ↗
Cleveland Clinic 4 Benefits of Olive Oil for Skin

Dermatologist Dr Amy Kassouf explains how olive oil can be used topically — and when to exercise caution.

Read Article ↗
Healthline 11 Proven Benefits of Olive Oil

A comprehensive, medically reviewed overview of the evidence base — covering everything from cholesterol to Alzheimer's prevention.

Read Article ↗
American Heart Association The Benefits of Adding Olive Oil to Your Diet

The AHA's position on olive oil as a heart-healthy fat, covering MUFAs, polyphenols and cardiovascular disease prevention.

Read Article ↗
Yale School of Medicine Olive Oil and Heart Health

Yale's analysis of the landmark 28-year, 90,000-person Harvard study and its implications for clinical dietary recommendations.

Read Article ↗
Vogue Olive Oil Benefits: What Happens to Your Body

A lifestyle-focused look at the benefits of daily olive oil consumption — from skin and hair to energy and digestion.

Read Article ↗
Women's Health What Happens When You Have Olive Oil Every Day

The surprising daily benefits of making EVOO a consistent part of your routine — including some less well-known effects.

Read Article ↗
New York Post Why You Should Take a Spoonful of Olive Oil Each Day

The case for the daily olive oil habit — what the research says about a simple morning practice and its cumulative health effects.

Read Article ↗

Everything You Want to Know
About Olive Oil & Health

Answers to the questions we hear most often — from guests at the farm, from customers, and from the searches that bring people to this page.

Val d'Orcia Olive Oil,
Delivered to Your Door

Podere Spedalone's certified organic extra virgin olive oil is available in gift sets of three bottles — Canino, Frantoio, and our signature blended and less-filtered varieties. Cold-pressed, hand-harvested, and shipped worldwide.

🫙 Shop Our Olive Oil Learn About Our Varieties →

The information on this page is provided for general educational purposes and is drawn from peer-reviewed research and recognised health institutions. It does not constitute medical advice and should not be used to diagnose, treat, or prevent any health condition. Consult a qualified healthcare professional before making significant dietary changes, particularly if you have an existing medical condition or are taking medication. Individual results vary.

✎ Last reviewed and updated:

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